INDICATIONS AND USAGE
Dacarbazine for Injection is indicated in the treatment of metastatic malignant melanoma. In addition, Dacarbazine for Injection is also indicated for Hodgkin's disease as a second-line therapy when used in combination with other effective agents.

WARNING

It is recommended that Dacarbazine for Injection be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.

1. Hemopoietic depression is the most common toxicity with Dacarbazine for Injection (see WARNINGS).
2. Hepatic necrosis has been reported (see WARNINGS).
3. Studies have demonstrated this agent to have a carcinogenic and teratogenic effect when used in animals.
4. In treatment of each patient, the physician must weigh carefully the possibility of achieving therapeutic benefit against the risk of toxicity.

Please refer to full prescribing information.

Leukopenia and thrombocytopenia are common and may be severe enough to be fatal. Anorexia, nausea and vomiting are also frequent adverse events.